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More resources are also available at Breast Cancer Hope forum.

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Recently, we reported that 2’–5’ oligoadenylate synthetase-like 1 (OASL1) negatively regulates type I IFN production by inhibiting the translation of the type I IFN-regulating master transcription factor, IRF7.

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Furthermore, whether OASL1 also regulates type III IFNs has not been investigated.

Together, these results indicate that OASL1-mediated negative regulation of type I IFN production suppresses both innate and adaptive immunity against mucosal HSV-2 infection.

For example, protein kinase R (PKR), the ds RNA-activated serine/threonine protein kinase, is an ISG that negatively regulates m RNA translation.

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