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The discussion topic will focus on post translational modifications for monoclonal antibodies.

Basically, what types of modification are observed during development, which have biological/DMPK ramifications, and what preclinical strategies are pragmatic in managing these CMC issues Kathila Rajapaksa from Genentech will give a short (10–15 minute) introduction and then help lead the discussion.

Topics to be covered include: Once a lead molecule is identified for further development, what do the formulation folks do? Northern California Regional Chapter Fall Symposium October 21, 2014, AM– PM Venue: Genentech Building 42, South San Francisco Symposium Agenda, Speaker Bios, and Abstract Information Northern California Regional Chapter Spring Symposium April 29, 2014, AM– PM Venue: David Brower Center, 2150 Allston Way, Berkeley, CA Topics: safety profiling of drugs and chemicals, neurotoxicology, neuroelectrophysiology, screening for drug abuse liability, current topics in therapeutic proteins, and more!

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This training course will describe a practical, materials-based approach to manage risk that has worked in meeting the US FDA’s expectations for equipment evaluations.

Northern California 2016 Spring Symposium Tuesday, April 26, 2016—SRI International, Menlo Park, California We have an exciting line up covering diverse topics including latest advances in ADCs, epigenetics, reprotox, and genetox (agenda below).

The idea, as before, is to get to know others in our field and to learn from each other.

Tuesday, July 23, 2013 Sapore Italiano 1447 Burlingame Ave, Burlingame, CA 94010 Nor Cal 2013 Spring Symposium Tuesday, April 23, 2013 South San Francisco Convention Center 225 South Airport Blvd, South San Francisco The Nor Cal Society of Toxicology Presents: Speed Mentoring Wednesday, January 30, 2013 PM– PM Pyramid Alehouse 901 Gilman St.

Nor Cal SOT Reception—2014 Annual Meeting, Phoenix, Arizonia.

Date: Tuesday, March 25 Location: Arrogant Butcher, 2 E Jefferson St, Ste 150, Phoenix AZ 85004 Time: PM– PM Nor Cal SOT Preclinical Drug Safety Networking Dinner Wednesday, December 4, 2013 Sapore Italiano 1447 Burlingame Ave Burlingame, CA 94010 Nor Cal 2013 Fall Symposium Thursday, October 24, 2013 South San Francisco Convention Center 225 South Airport Blvd South San Francisco, California Speed Mentoring Tuesday, October 1, 2013 Sudwerk 2001 2nd Street Davis, CA 95618 Nor Cal SOT Preclinical Drug Safety Networking Dinner—Open Forum After three popular events in 2012, we are organizing another dinner for those involved in pharmaceutical research and development.Special Joint SJSU MBT - SOT Seminar Thursday, December 4, 2014 Venue: Chalet Ticino, 1058-C Shell Boulevard, Foster City, CA 94404 (in Charter Square Center) Nor Cal SOT Preclinical Drug Safety Networking Dinner There’s no Formula to Formulation Where: Chalet Ticino Address: 1058-C Shell Boulevard, Foster City, CA 94404 (in Charter Square Center) Date: Thursday, December 4 Time: PM The Bay area toxicology discussion group is looking forward to our next get-together on December 4, 2014.We will start the evening with network time with wine and appetizers.We are in need of volunteers to serve as expert toxicologists addressing parents and students questions during the day and supporting the Tox Sa student when needed. The event will be held at the following location: LGI Room, Audubon Elementary School, 841 Gull Avenue, Foster City, California 94404 This is a fun event that has become a tradition for Nor Cal and we look forward to your participation.If you are interested to volunteer, please email Toufan Parman.K–12 Event April 6, 2014, PM– PM We are planning another K–12 education event in collaboration with Berkeley Toxicology Student Association (Tox SA) and Girl Scouts.

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